Device scopes out infection behind eardrum

A new medical imaging device is able to peek behind the eardrum to diagnose and treat chronic ear infections. The device could usher in other non-invasive, 3-D diagnostic tools for primary-care physicians, researchers say. Ear infections are the most common conditions that pediatricians treat. Chronic ear infections can damage hearing and often require surgery to place drainage tubes in the eardrum. Problems can persist into adulthood. Studies have found that patients who suffer from chronic ear infections may have a film of bacteria or other microorganisms that builds up behind the eardrum, very similar to dental plaque on unbrushed teeth. Finding and monitoring these so-called biofilms are important for successfully identifying and treating chronic ear infections. “We know that antibiotics don’t always work well if you have a biofilm, because the bacteria protect themselves and become resistant,” explains Stephen Boppart, a professor of electrical and computer engineering at the University of Illinois who led the research. “In the presence of a chronic ear infection that has a biofilm, the bacteria may not respond to the usual antibiotics, and you need to stop them. But without being able to detect the biofilm, we have no idea whether or not it’s responding to treatment.” However, middle-ear biofilms are difficult to diagnose. A doctor looking through a standard otoscope sees only the eardrum’s surface, not the bacteria-seeded biofilm lurking behind it waiting to bloom into infection. Invasive tests can provide evidence of a biofilm, but are unpleasant for the patient and cannot be used routinely. Described in Proceedings of the National Academy of Sciences, the new device is an application of a technique called optical coherence tomography (OCT), a non-invasive imaging system devised by Boppart’s group. It uses beams of light to collect high-resolution, three-dimensional tissue images, scanning through the eardrum to the biofilm behind it—much like ultrasound imaging, but using light. “We send the light into the ear canal, and it scatters and reflects from the tympanic membrane and the biofilm behind it,” says graduate student Cac Nguyen, the lead author of the paper. “We measure the reflection, and with the reference light we can get the structure in depth.” The single scan is performed in a fraction of a second—speed is a necessity for treating squirming tots—and images a few millimeters deep behind the eardrum. Thus, doctors can see not only the presence of a biofilm, but also how thick it is and its position against the eardrum. “I think this is now a technology that allows physicians to monitor chronic ear infection, and examine better ways to treat the disease,” says Boppart, who is also affiliated with the departments of bioengineering and internal medicine, the Institute for Genomic Biology, and the Beckman Institute for Advanced Science and Technology at Illinois. “We can use different antibiotics and see how the biofilm responds.” The researchers hope to make their device—currently a hand-held prototype—even more compact, easy to use, and low-cost. The device company Welch Allyn, based in Skaneateles Falls, N.Y., is a collaborator on the project, which was funded by the National Institutes of Health. Boppart’s group and its collaborators also will work to apply OCT imaging to other areas commonly examined by primary-care physicians. The ear-imaging device is the first in a suite of OCT-based imaging tools that the group plans to develop. Doctors could change the tip of the new OCT device, for example, to look at the eyes, mouth, nose, or skin. “All the sites that a primary-care physician would look at, we can now look at with this more advanced imaging,” Boppart says. “With OCT, we are bringing to the primary-care clinic high-resolution 3-D digital imaging and being able to look at many different tissue structures in real-time, non-invasively and in depth. As medicine gets more high-tech, we want to give the front-line doctor the best technology to detect disease early.”